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IDEC ABN101

Home Products IDEC power switch buttons IDEC ABN101

IDEC ABN101

  • Product Item:ABN101
  • ABN101
  • ABN101
  • ABN101
  • ABN101
  • Category:IDEC power switch buttons
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    Description


    Key Specifications Table

    Species Reactivity Key Applications Host Format Antibody Type
    H, M, R, Ca, Po WB Rb Affinity Purified Polyclonal Antibody
    Description
    Catalogue Number ABN101
    Description Anti-GAD65 Antibody
    Alternate Names
    • Glutamate decarboxylase 2
    • 65 kDa glutamic acid decarboxylase
    • GAD-65
    • Glutamate decarboxylase 65 kDa isoform
    Background Information GAD65 is a group II decarboxylase enzyme that catalyzes the biosynthesis of GABA from glutamate with the aid of the cofactor, pyridoxal 5'-phosphate. GAD65 localizes at presynaptic GABAergic terminals and is reported to supply local vesicular pools of GABA facilitating transient inhibitiory neurotransmission, although GAD65 may also play a role in more sustained tonic inhibitory signals. It is present as a dimer of alpha and beta subunits and is regulated by alternative splicing, which may produce the GAD67 isoform. GAD65 also undergoes post-translational modifications such as palmitoylation of N-terminal cysteine residues and phosphorylation of multiple alpha-subunit serine residues that enable membrane-anchoring and other vesicular activities. GAD65 has been implicated in neurological conditions resulting from failure of inhibitory neurotransmission such as Huntington's disease and epilepsy. In addition to its CNS presence, GAD65 also produces GABA in pancreatic beta cells and dysfunction in this area may contribute to the pathogenesis of insulin-dependent diabetes mellitus.
    Product Information
    Format Affinity Purified
    Control
    • Rat brain membrane tissue lysate
    Presentation Purified Rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    Quality Level MQ100
    Applications
    Application Anti-GAD Antibody is an antibody against GAD65 for use in Western Blotting. See below for more information about this anti GAD antibody.
    Key Applications
    • Western Blotting
    Application Notes Western Blot Analysis: 1 µg/mL from a representative lot detected GAD65 on 10 µg of rat brain membrane tissue lysate. Western Blot performed without Tween.
    Biological Information
    Immunogen KLH-conjugated linear peptide corresponding to human GAD65.
    Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
    Host Rabbit
    Species Reactivity
    • Human
    • Mouse
    • Rat
    • Canine
    • Pig
    Species Reactivity Note Demonstrated to react with Rat, Mouse, and Human. Predicted to react with Canine and Porcine based on 100% sequence homology.
    Antibody Type Polyclonal Antibody
    Entrez Gene Number
    • NP_000809
    Gene Symbol
    • GAD2
    • GAD65
    Purification Method Affinity Purfied
    UniProt Number
    • Q05329
    Molecular Weight ~59/63 kDa observed. The calculated molecular weight is 65 kDa, however GAD65 has been shown as a ~59/63 doublet in western blots. (Christgau, S., et al. (1991). Journal of Biological Chemistry. 266(31):21257-21264.) An uncharacterized band appears at ~38 kDa in some lysates.
    Product Usage Statements
    Quality Assurance Evaluated by Western Blot in rat brain membrane tissue lysate.
    Western Blot Analysis: 1 µg/mL of this antibody detected GAD65 on 10 µg of rat brain membrane tissue lysate.
    Usage Statement
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    Storage and Shipping Information
    Storage Conditions Stable for 1 year at 2-8°C from date of receipt.
    Packaging Information
    Material Size 100 µg
    We have  52pcs in stock ,
    please contact emails :
    sales@gbloong.com
    sales@autotektools.com


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    Product Categories

    • IDEC selection switches
    • IDEC emergency stop switches
    • IDEC terminals
    • IDEC rails
    • IDEC safety barriers
    • IDEC PLC
    • IDEC time relays
    • IDEC warning signs
    • IDEC enable switches
    • IDEC signs
    • IDEC safety door locks
    • IDEC safety door lock pins
    • IDEC buzzers
    • IDEC transformers
    • IDEC LED lamp beads
    • IDEC power switch buttons
    • IDEC circuit breakers
    • IDEC switch boxes
    • IDEC power supplys
    • IDEC indicator lights
    • IDEC relays
    • IDEC protective covers
    • IDEC relay holders
    • IDEC cross switches
    • IDEC contacts
    • IDEC key switches
    • IDEC accessories
    • Tape dispensers

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